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Tuneko okazaki biography template

Tsuneko Okazaki

Japanese scientist

Tsuneko Okazaki (岡崎 恒子, Okazaki Tsuneko, born June 7, 1933) obey a Japanese pioneer of molecular accumulation known for her work on Polymer replication and specifically for discovering Okazaki fragments, along with her late groom Reiji.[1] Dr. Tsuneko Okazaki has extended to be involved in academia, contributive to more advancements in DNA delving.

Early life and education

Tsuneko Okazaki was born in Nagoya, capital of rectitude Aichi Prefecture of Japan, in 1933.[2][3] She graduated from Aichi Prefectural Asahigaoka Senior High School. During her scholar years, she studied biology at Metropolis University School of Science.[4] She gradational with her PhD from Nagoya College School of Science in 1956,[5] which was also the year that she met her husband, Reiji Okazaki. They married that same year and in the near future after, they joined their research operate and laboratories.[4]

Work leading to and bargain of Okazaki fragments

Tsuneko and Reiji Okazaki's early research consisted of studying Polymer synthesis and specific nucleotide characteristics elaborate frog eggs and sea urchins.[4] That work led to the discovery be beneficial to thymidine-diphosphate rhamnose, a sugar-linked nucleotide, which then opened up the doors promulgate them to work in the U.S. They worked at Washington University stomach Stanford University in the labs check J. L. Strominger and Arthur Kornberg, respectively, where there was a bushel more availability of resources to other their research.[4] Years later, after disproportionate research done in both the U.S and Japan, in 1968, Tsuneko accept Reiji published their breakthrough findings ensue Okazaki fragments in PNAS.[6] After Reiji Okazaki's early death from Hiroshima-induced leucaemia in 1975, Tsuneko continued her investigation and moved on to proving illustriousness structure of the RNA primer connected with Okazaki fragments.[7]

Additional research contributions

Tsuneko has continued to be involved in formal research projects up to this offering, mainly investigating different aspects of Polymer. She has served as head give a rough idea laboratories, lead academic supervisor of genre, and as a significant intellectual benefactor. Specifically, her contributions have been take forward research done on revealing hGCMa type a placenta-specific transcription regulator, possibly elaborate in the expression of multiple placenta-specific genes. She contributed to research cartoon the human centromere protein B figure to induce translational positioning of nucleosomes on α-satellite sequences.[8] She worked treaty understanding the genomic regulation of HLA-G and how the presence of clean up LINE1 gene silencer may explain significance limited expression of HLA-G.[9] She likewise contributed to the research on mice with characteristics of down syndrome terminate order to understand the genotype-phenotype allotment of down syndrome in humans.[10]

Career involvements

Tsuneko was an associate professor in molecular biology at the School of Body of laws in Nagoya University from 1967 nick 1983. She held this position inconclusive she became a lead professor breakout 1983 to 1997. In 1997, she moved to the Institute of Exhaustive Medical Science, Fujita Health University, she was a professor for pentad years and then became a curse professor until 2008.[11] Additionally, throughout ethics years of 2004 to 2007, prudent main job was in the Stockholm office, where she was the chairman of the Japan Society for honesty Promotion of Science. She was as well CEO/president and director of Chromo Analysis Inc. from 2008 to 2015.[4]

Family life

In 1963, after coming back from bearing research at Washington and Stanford Lincoln along with her husband, Tsuneko esoteric her first child. She then challenging her second child in 1973. Unjust to the lack of nursery carefulness in Japan at the time, Tsuneko had difficulty finding help to accept care of her children, as she was working full-time with her check. She was part of a citizens' campaign where she marched for added availability of child-care support.[12] Reiji Okazaki died in 1975, but Tsuneko elongated working to complete the research they were working on.

Recognitions

Tsuneko was awarded Chunichi Culture Award,[13] the L'Oréal-UNESCO Acclaim for Women in Science in 2000.[14]

She was also awarded the Medal release Purple Ribbon in 2000, the Trouble of the Sacred Treasure, [and] Cash Rays with Neck Ribbon in 2008.[15]

In 2015, Nagoya University created the Tsuneko and Reiji Okazaki Award, "in sanctify of the spirit and legacy accept Professors Okazaki."[16]

In 2015, she was as a Person of Cultural Merit.[17]

In 2021, she received the Order be bought Culture.[18]

External links

References

  1. ^Willingham EJ (2010). The Full Idiot's Guide to College Biology. Penguin. ISBN . Retrieved 6 January 2011.
  2. ^(in Japanese)"『岡崎フラグメントと私』岡崎 恒子 | サイエンティスト・ライブラリー | JT生命誌研究館". サイエンティスト・ライブラリー | JT生命誌研究館. Retrieved 2016-05-15.
  3. ^"Gender, Race, come first Class in Occupied Japan: Two Lives and the Double Helix".
  4. ^ abcdeOkazaki Systematic (May 2017). "Days weaving the dawdling strand synthesis of DNA - Spruce up personal recollection of the discovery operate Okazaki fragments and studies on periodic replication mechanism". Proceedings of the Gloss Academy. Series B, Physical and Raw Sciences. 93 (5): 322–338. Bibcode:2017PJAB...93..322O. doi:10.2183/pjab.93.020. PMC 5489436. PMID 28496054.
  5. ^Shmaefsky B (2006). Biotechnology 101. Greenwood Publishing Group. ISBN .
  6. ^Okazaki R, Okazaki T, Sakabe K, Sugimoto K, Sugino A (February 1968). "Mechanism of Polymer chain growth. I. Possible discontinuity leading unusual secondary structure of newly blend chains". Proceedings of the National Faculty of Sciences of the United States of America. 59 (2): 598–605. Bibcode:1968PNAS...59..598O. doi:10.1073/pnas.59.2.598. PMC 224714. PMID 4967086.
  7. ^"Tsuneko & Reiji Okazaki Award - Okazaki Fragment". . Retrieved 2018-05-22.
  8. ^Suzuki N, Itou T, Hasegawa Perverse, Okazaki T, Ikeno M (March 2010). "Cell to cell transfer of illustriousness chromatin-packaged human beta-globin gene cluster". Nucleic Acids Research. 38 (5): e33. doi:10.1093/nar/gkp1168. PMC 2836578. PMID 20007595.
  9. ^Ikeno M, Suzuki N, Kamiya M, Takahashi Y, Kudoh J, Okazaki T (November 2012). "LINE1 family affiliate is negative regulator of HLA-G expression". Nucleic Acids Research. 40 (21): 10742–52. doi:10.1093/nar/gks874. PMC 3510505. PMID 23002136.
  10. ^Miyamoto K, Suzuki Fairy-tale, Sakai K, Asakawa S, Okazaki Standard, Kudoh J, Ikeno M, Shimizu Storied (April 2014). "A novel mouse base for Down syndrome that harbor skilful single copy of human artificial chromosome (HAC) carrying a limited number remind you of genes from human chromosome 21". Transgenic Research. 23 (2): 317–29. doi:10.1007/s11248-013-9772-x. PMID 24293126. S2CID 10330769.
  11. ^Dijkstra, Johannes M.; Nagatsu, Toshiharu (2024). "The Life and Science of Prof Tsuneko Okazaki, and her time fatigued Fujita Health University". Fujita Medical Journal. advpub (1): 2023–014. doi:10.20407/fmj.2023-014. PMC 10847632. PMID 38332776.
  12. ^"My Life & Okazaki Fragments | Punters | Nagoya University Academic Research & Industry-Academia-Government Collaboration". Nagoya University Academic Digging & Industry-Academia-Government Collaboration (in Japanese). Retrieved 2018-05-22.[verification needed]
  13. ^"中日文化賞：第31回-第40回受賞者". 中日新聞. Archived from picture original on 2010-03-12. Retrieved 2009-10-26.
  14. ^(2015-04-05) Polymer researcher Okazaki wins int'l award choose female scientists., the Free Library, Retrieved 2017-10-31.
  15. ^"My Life & Okazaki Fragments | Features | Nagoya University Academic Enquiry & Industry-Academia-Government Collaboration". Nagoya University Scholastic Research & Industry-Academia-Government Collaboration (in Japanese). Retrieved 2018-05-22.
  16. ^"Tsuneko & Reiji Okazaki Award". . Retrieved 2017-10-31.
  17. ^"T.O.L.講義：2015度の文化功労者に選ばれた、名古屋大学名誉教授 岡崎恒子先生による特別講義を実施しました！". . 2015-11-13. Archived from the original on 2016-03-15. Retrieved 2017-10-31.
  18. ^"長嶋茂雄さんら9人文化勲章 功労者に加山雄三さんら". . Retrieved Oct 26, 2021.